Fully-automated synthesis of 177Lu labelled FAPI derivatives on the module modular lab-Eazy

Abstract Background To the best of our knowledge, manually production [ 177 Lu]Lu-FAPI radiopharmaceutical derivatives has been only described in literature. In this work, a fully-automated synthesis well designed for first time using commercially available module. addition to development an automated system with disposable cassette, quality control (QC) and stability studies were comprehensively presented. Results A fully was achieved on Modular Lab Eazy (ML Eazy) high radiochemical yield ([ Lu]Lu-FAPI-04; 88% ± 3, Lu]Lu-FAPI-46; 86% 3). Chromatographic analysis indicated formation radiosynthesis absolute purity (99%). Stability experiments clarified durability products within 4 days. All obtained specifications are consistent European Pharmacopoeia. Conclusion radiopharmaceuticals accomplished regarding standards assurance by modular approach namely ML customized cassette template. Graphical abstract